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M Ezban Selected Research

recombinant FVIIa (rFVIIa)

11/2017The pharmacokinetics and pharmacodynamics of single-dose and multiple-dose recombinant activated factor VII in patients with haemophilia A or B.
1/2016An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.
9/2011Monitoring rFVIIa 90 μg kg⁻¹ dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h.
2/2011Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients.
3/2010Animal models of FVIIa gene expression: their role in the future development of haemophilia treatment.
3/2010Effect of glycoPEGylation on factor VIIa binding and internalization.
12/2009Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig.
11/2009Thrombin generation and platelet activation induced by rFVIIa (NovoSeven) and NN1731 in a reconstituted cell-based model mimicking haemophilia conditions.
9/2009Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice.
4/2009rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats.
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M Ezban Research Topics

Disease

17Hemophilia A (Haemophilia)
01/2018 - 09/2009
14Hemorrhage
11/2017 - 02/2007
4Hemophilia B (Haemophilia B)
11/2017 - 11/2009
3Wounds and Injuries (Trauma)
01/2016 - 04/2000
2Acute Lung Injury
11/2001 - 10/2001
2Thrombosis (Thrombus)
02/2001 - 04/2000
2Infarction (Infarctions)
05/2000 - 04/2000
1von Willebrand Diseases (von Willebrand's Disease)
01/2016
1Body Weight (Weight, Body)
09/2011
1Sepsis (Septicemia)
11/2001
1Inflammation (Inflammations)
11/2001
1Edema (Dropsy)
10/2001
1Thrombocytopenia (Thrombopenia)
07/2001
1No-Reflow Phenomenon
05/2000
1Vascular Diseases (Vascular Disease)
04/2000
1Carotid Stenosis (Carotid Artery Stenosis)
04/2000
1Vascular System Injuries
04/2000
1Carotid Artery Thrombosis
04/2000
1Myocardial Infarction
04/2000

Drug/Important Bio-Agent (IBA)

15recombinant FVIIa (rFVIIa)FDA Link
11/2017 - 04/2000
13Factor VIIa (Activated Factor VII)IBA
01/2018 - 04/2000
6Thromboplastin (Tissue Factor)IBA
10/2017 - 04/2000
5Factor VIII (Coagulation Factor VIII)IBA
05/2017 - 11/2009
5NN1731IBA
12/2009 - 05/2008
4ThrombinFDA Link
11/2017 - 07/2001
3recombinant factor VIII N8IBA
01/2016 - 11/2012
2nonacog beta pegolIBA
11/2017 - 10/2017
2Factor IX (Coagulation Factor IX)FDA LinkGeneric
01/2016 - 11/2009
2CytokinesIBA
11/2001 - 10/2001
2FibrinIBA
11/2001 - 10/2001
1AntibodiesIBA
01/2018
1Indicators and Reagents (Reagents)IBA
10/2017
1Proteins (Proteins, Gene)FDA Link
01/2016
1Blood Coagulation Factors (Coagulation Factor)IBA
11/2015
1CoagulantsIBA
09/2012
1AntithrombinsIBA
02/2011
1vasectrin I (VS I)IBA
12/2009
1recombinant factor VIII SQIBA
09/2009
1anti-inhibitor coagulant complexIBA
09/2009
1Prothrombin (Factor II)IBA
09/2009
1Clopidogrel (Plavix)FDA Link
04/2009
1Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
05/2008
1A-factor (Streptomyces)IBA
05/2008
1Heparin (Liquaemin)FDA LinkGeneric
05/2008
1Tinzaparin (Innohep)FDA Link
05/2008
1Fibrinogen (Factor I)FDA Link
11/2001
1lipoprotein-associated coagulation inhibitor (TFPI)IBA
11/2001
1Interleukin-6 (Interleukin 6)IBA
11/2001
1Pharmaceutical PreparationsIBA
10/2001
1Factor VII (Proconvertin)IBA
04/2000
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
04/2000

Therapy/Procedure

4Therapeutics
01/2016 - 04/2000
1Injections
11/2017
1Intravenous Administration
02/2011